Anaemia

Haemolytic anaemia.

Pernicious anaemia.

DEFICIENCY of vitamin B12 (cyanocobalamin) in man results in a macrocytic animia, leucopa2nia, the appearance of megaloblasts and giant band cells in the marrow, reduced formation of platelets, and also-changes in the peripheral and central nervous systems. In temperate climates the most common cause of vitamin B12 deficiency is pernicious anaemia. This is by no means a rare disease, having an ...

Fanconi anaemia

Growth retardation (70% of cases). Skin abnormalities: hyperpigmentation and/or café au lait spots in 80%. Squeletal malformations (60%), particularly radius axis defects (absent or hypoplastic thumb or radius...). No immune deficiency (in contrast with most other chromosome instability syndromes). Progressive bone marrow failure; mean age of onset of anemia: 8 yrs; diagnosis made before onset ...

Malarial anaemia and nitric oxide induced megaloblastic anaemia: a review on the causes of malarial anaemia.

Direct destruction and ineffective erythropoesis does not adequately explain the cause of anaemia in malaria. It is possible that there are more other mechanisms involved besides the causes described till date in malarial anaemia. The effect of NO on erythropoesis and a major haematological abnormality (microcytic/normocytic/megaloblastic picture) can significantly be observed on repeated expos...

Aplastic Anaemia.